Table 1 Clinicopathological features of large duct type adenocarcinoma compared with ordinary ductal adenocarcinoma cases
Large duct type adenocarcinoma, (28 cases) | Ordinary ductal adenocarcinoma, (202 cases) | P-value | |
|---|---|---|---|
Mean Age (years) | 67 | 63 | 0.01 |
Gender | |||
Female | 19 (70%) | 105 (53%) | 0.08 |
Male | 8 (30%) | 93 (47%) | |
Tumor location | |||
Head | 16 (60%) | 154 (82%) | 0.006 |
Tail | 11 (40%) | 33 (18%) | — |
Median survival (months) | 16 | 12 | 0.6 |
1-year survival | 77% | 52% | — |
2-year survival | 30% | 30% | — |
Tumor size (cm) | 4.1 | 3.4 | 0.1 |
Stage | |||
I | 4/27 (15%) | 25/168 (15%) | 0.02 |
II | 6/27 (22%) | 49/168 (29%) | — |
III | 12/27 (44%) | 88/168 (52%) | — |
IV | 5/27 (19%) | 6/168 (4%) | — |
Extent of tumor 6 | |||
EP | 21/25 (84%) | 109/119 (92%) | 0.2 |
Duodenum | 8/25 (32%) | NA | — |
Stomach + Colon | 3/25 (12%) | NA | — |
Cases with LN metastasis | 16/23 (70%) | 87/140 (62%) | 0.5 |
Average number of metastatic LN | 2 | 3 | 0.3 |
Perineural invasion | 21/24 (88%) | NA | — |
Vascular invasion | 5/23 (22%) | NA | — |
Positive margins | 6/25 (24%) | NA | — |
