Figure 4 | Modern Pathology

Figure 4

From: Loss of ARID1A protein expression occurs as an early event in ovarian clear-cell carcinoma development and frequently coexists with PIK3CA mutations

Figure 4

Representative histological features and ARID1A immunoreactions in benign clear-cell adenofibroma (a, c, and e) and borderline clear-cell adenofibroma (b, d, and f). (a) A case of benign clear-cell adenofibroma lacking cytological or structural atypia. (b) A case of borderline clear-cell adenofibroma. Epithelial cells show a moderate degree of cytological atypia. (c, d) Stromal cells are diffusely immunoreactive for ARID1A, while the immunoreaction is undetectable in epithelial cells. (e, f) Epithelial cells, as well as stromal cells, show diffuse immunoreactivity for ARID1A. (a, b) Hematoxylin and eosin (HE) staining, original magnification × 400 each. (c–f) Immunoperoxidase stain, original magnification × 400 each.

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