Table 1 The ARID1A immunoreactivity in the putative precursor lesions of ovarian clear-cell carcinomas

From: Loss of ARID1A protein expression occurs as an early event in ovarian clear-cell carcinoma development and frequently coexists with PIK3CA mutations

 

Number of cases (%)

 

ARID1A

ARID1A

Type of precursor lesion

Deficient

Intact

In the endometriosis-associated carcinomas

In the ARID1A-deficient carcinomas

Non-atypical endometriosis (distant; n=10)

0

10 (100)

Non-atypical endometriosis (adjacent; n=14)

12 (86)a

2 (14)

Atypical endometriosis (adjacent; n=14)

14 (100)

0

In the ARID1A-intact carcinomas

Non-atypical endometriosis (adjacent; n=7)

0

7 (100)

Atypical endometriosis (n=8)

0

8 (100)

In the adenofibroma-associated carcinomas

In the ARID1A-deficient carcinomas

Benign clear-cell adenofibroma (adjacent; n=3)

3 (100)

0

Borderline clear-cell adenofibroma (adjacent; n=6)

6 (100)

0

In the ARID1A-intact carcinomas

Benign clear-cell adenofibroma (adjacent; n=10)

0

7 (100)

Borderline clear-cell adenofibroma (adjacent; n=14)

0

7 (100)

  1. a Three of these 12 lesions exhibited a pattern of immunoreactivity in which areas of ARID1A-deficient cells were adjacent to the ARID1A-intact areas.