Figure 1 | Modern Pathology

Figure 1

From: Unique genetic profile of sporadic colorectal cancer liver metastasis versus primary tumors as defined by high-density single-nucleotide polymorphism arrays

Figure 1

Metastatic colorectal cancer genome for the 20 colorectal carcinoma patients genotyped on the Affymetrix 500 K SNP array platform. A summary plot showing the frequency (a (in the left)) and fluorescence intensity log2 ratios (b (in the left)) of those copy number gains (plotted in red above zero values in the x axis) and losses (plotted in green below zero values in the x axis) identified in primary sporadic colorectal tumors (light colors), and their paired liver metastases (dark color) are displayed for the whole genome. The panels in the right show abnormalities identified in primary sporadic colorectal tumors (light colors) and their paired liver metastases (dark color) for individual chromosomes, which showed new abnormalities in metastatic versus primary tumor samples (c–h), or displayed an increased frequency of abnormalities in metastatic samples, which were already detected in primary tumors (i–q). Arrows point to regions of interest.

Back to article page