Figure 2 | Modern Pathology

Figure 2

From: Unique genetic profile of sporadic colorectal cancer liver metastasis versus primary tumors as defined by high-density single-nucleotide polymorphism arrays

Figure 2

Metastatic colorectal cancer genome for the 20 colorectal carcinoma patients genotyped on the Affymetrix 500 K SNP array platform; copy number changes detected in liver metastases (n=8/20 cases; red color) versus their paired primary tumors (blue color) for the 4q27, 4q28.1, 4q34.1, 5p13.1, 6p25.2 and 10q23.33 chromosomal regions (a). Genes contained in the newly altered chromosomal regions are listed in italics capital letters. Log2 ratios >0.09 and <−0.09 (shown as colored background) were used as cut-off thresholds to define the presence of increased and decreased copy number values, respectively. All copy number changes detected between liver metastases versus their paired primary tumors showed statistically significant differences (P<0.001). As an example, the 3p14, 12q12 and 19q13 chromosomal regions, which did not show any differences between paired primary and metastatic lesions, are also shown (b).

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