Figure 4 | Modern Pathology

Figure 4

From: The spectrum of B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma: a description of 10 cases

Figure 4Figure 4

B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma (DLBCL) and classical Hodgkin lymphoma (CHL), pattern 4 (case 10, sequential composite type): histological sections of the initial biopsy show classical Hodgkin lymphoma, nodular sclerosis subtype with lacunar cells, Reed–Sternberg cells and mononuclear variants in a polymorphous background of eosinophils, histiocytes, lymphocytes and neutrophils (a). Immunohistological studies show that the Hodgkin cells express weak CD20 (b), CD30 (c) and CD15 (d). A subsequent biopsy of the mediastinum shows a monotonous and cohesive atypical large lymphoid proliferation with clear cytoplasm associated with geographic necrosis and delicate fibrosis without thickened sclerotic bands (e). Immunohistological studies show that these large atypical cells express CD45 (f), CD20 (g) and CD30 (h). Original magnification: × 200, × 400.

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