Figure 1 | Modern Pathology

Figure 1

From: Semi-quantitative immunohistochemical assay versus oncotype DX® qRT-PCR assay for estrogen and progesterone receptors: an independent quality assurance study

Figure 1

Modified H-score examples (range: 0 to 300). Case (a) (strong ER positive; H-score 300), 0: 0%, 1+: 0%, 2+: 0%, 3+: 100%. ER H-score=(0 × 0)+(1 × 0)+(2 × 0)+(3 × 100)=300. Case (b) (heterogeneous but still strong PR positive; H-score 205), 0: 25%, 1+: 5%, 2+: 10%, 3+: 60%. PR H-score=(0 × 25)+(1 × 5)+(2 × 10)+(3 × 60)=205. Case (c) (moderate ER positive; H-score 135), 0: 10%, 1+: 50%, 2+: 35%, 3+: 5%. ER H-score=(0 × 10)+(1 × 50)+(2 × 35)+(3 × 5)=135. Case (d) (weak PR positive; H-score 30), 0: 85%, 1+: 5%, 2+: 5%, 3+: 5%. PR H-score=(0 × 85)+(1 × 5)+(2 × 5)+(3 × 5)=30.

Back to article page