Table 2 Correlation of mismatch repair protein immunohistochemical staining pattern and microsatellite PCR analysis in colorectal adenocarcinoma for both retrospective and prospective groups

From: A two-antibody mismatch repair protein immunohistochemistry screening approach for colorectal carcinomas, skin sebaceous tumors, and gynecologic tract carcinomas

Immunohistochemical pattern

No. of cases

No. of cases tested for MSI

Microsatellite status

   

MSS (%)

MSI-L (%)

MSI-H (%)

Loss of at least 1 protein

59

49

4 (8)

6 (12)

39 (80)

Loss of MLH1 and PMS2

34

29

0 (0)

1 (3)

28 (97)

Loss of PMS2 alone

5

2

0 (0)

1 (50)

1 (50)

Loss of MSH2 and MSH6

12

12

2 (17)

1 (8)

9 (75)

Loss of MSH6 alone

8

6

2 (33)

3 (50)

1 (17)

All proteins tested intact

264

206

206 (100)

0 (0)

0 (0)

  1. MSS, microsatellite stable; MSI-L, microsatellite instability low; MSI-H, microsatellite instability high.
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