Table 3 Mismatch repair protein immunohistochemical staining pattern and microsatellite instability status of gynecologic tract carcinomas for both retrospective and prospective groups
Immunohistochemical pattern (%) | Uterine primary carcinoma | Ovarian primary carcinoma | ||||||
|---|---|---|---|---|---|---|---|---|
Grade 1 endometrioid (n=17) | Grade 2 endometrioid (n=3) | Grade 3 endometrioid (n=16) | Clear cell (n=4) | Grade 1 endometrioid (n=1) | Grade 3 endometrioid (n=4) | Clear cell (n=3) | Serous (n=2) | |
Loss of MLH1 and PMS2 | 2 | 0 | 7 | 0 | 0 | 1 | 0 | 0 |
Loss of MSH2 and MSH6 | 1 | 1 | 2 | 0 | 0 | 0 | 0 | 0 |
Loss of MSH6 alone | 1 | 1 | 2 | 0 | 1 | 0 | 0 | 0 |
Equivocal MSH6 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Loss of at least 1 protein | ||||||||
Microsatellite unstablea | 4 | 2 | 11 | 0 | 1 | 1 | 0 | 0 |
No. tested | 0/1 | 1/2 | 3/5 | NA | Not tested | 1/1 | NA | NA |
All proteins tested intact | ||||||||
Microsatellite unstable | 11 | 1 | 5 | 4 | 0 | 3 | 3 | 2 |
No. tested (%) | 0/1 | 0/1 | None tested | 0/1 | NA | 0/2 | 0/1 | None tested |
