Table 5 Selected literature reports on patterns of immunohistochemical staining for MLH1, MSH2, MSH6, and PMS2 in extraintestinal neoplasms
Tumor site | Reference | Total no. | Abnormal mismatch repair protein immunohistochemical staining pattern | All intact | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
MLH1/PMS2 | MLH1-only | PMS2-only | MSH2/MSH6 | MSH2-only | MSH6-only | Other patterns | ||||
Skin sebaceous tumor | Orta et al19 | 27 | 2 | 0 | 1 | 8 | 0 | 1 | 0 | 15 |
Gynecologic tract | Modica et al39 | 85 | 23 | 0 | 6 | 6 | 1 | 9 | 1 with PMS2/MSH6, 2 with MLH1/PMS2/MSH6 | 37 |
Gynecologic tract | Garg et al40 | 71 | 19 | 0 | 0 | 9 | 0 | 4 | 0 | 39 |
Gynecologic tract | Backes et al41 | 140 | 24 | 0 | 0 | 4 | 0 | 2 | 0 | 110 |
Ampulla of Vater | Agaram et al42 | 54 | 1 | 0 | 0 | 0 | 0 | 2 | 0 | 51 |
