Table 3 Tumor heterogeneity according to KRAS mutational status in colorectal cancer patients

From: Metastatic colorectal cancer KRAS genotyping in routine practice: results and pitfalls

Patient no

Event type

Tumor localization

KRAS status

72

Primary tumor

Colon

c.38G>A

 

Metastasis

Lymph node

WT

221

Primary tumor

Rectum

WT

 

Metastasis

Liver

c.35G>T

436

Primary tumor

Colon

c.35G>A

 

Metastasis

Lymph node

WT

512a

Primary tumor

Colon

WT

 

Synchronous metastasis biopsy

Liver

c.34G>C, c.34G>T

89

Primary tumor

Colon

c.38G>A

 

Metastasis

Liver

WT

98b

T1, pT2N0 primary tumor

Rectum

c.34G>T

 

T2, pT3N0 primary tumor

Colon

WT

288

T1, pT3N0Mx primary tumor

Colon

c.35G>A

 

T2, pT2N0Mx primary tumor

Colon

WT

541

T1, pT3N1 primary tumor

Colon

WT

 

T2, pT3N2 primary tumor

Rectum

c.35G>T

811

T1, primary tumor

Duodenum

c.35G>T

 

T2, primary tumor

Colon

WT

897

T1, primary tumor

Sigmoid

WT

 

T2, primary tumor

Cecum

c.34G>T

903

T1, ypT3N0Mx

Colon

c.34G>T

 

T2, ypT3N0Mx

Colon

c.35G>T

90

T1, pT3N2Mx primary tumor

Colon

c.35G>A

 

T2, pT3N2Mx primary tumor

Cecum

WT

  1. aThe liver metastasis tumorectomy obtained 2 years later was KRAS WT.
  2. bThe liver metastasis investigated 2 years later was KRAS WT.