Table 3 Summary of molecular alterations in pancreatic acinar cell carcinomas reported in the literature

From: Analysis of LKB1 mutations and other molecular alterations in pancreatic acinar cell carcinoma

Genetic alteration

Cases studied

Abnormal cases (%)

References

KRAS

36

1 (3%)

2,7,8,11

TP53

69

0 (0%)

2,7,9,10,11,12

CDKN1A mutation

6

0 (0%)

11

SMAD4

35

0 (0%)

10,11,12

APC/CTNNB1

17

4a (24%)

10

MSI

13

3b (23%)

10

Gain at 1q, 12p, Xq,

6

NA (50–60%)

24

Loss at 16p, 16q

6

NA (50%)

24

Loss at 1p, 4q, 17p

9

NA (>70%)

12

Loss at 11q, 13q, 15q, 16q

9

NA (60–70%)

12

Loss at 3q, 6q, 8q, 18q, 21q

9

NA (50–60%)

12

Loss of 11p

12

6 (50%)

10

  1. Abbreviations: MSI, microsatellite instability; NA, not applicable.
  2. a1 CTNNB1 mutation, 3 APC mutations.
  3. b1 MSI-high, 2 MSI-low.