Table 5 Sensitivity, specificity, PPV, and NPV for the MV model and semiquantitative assessment of SRCs in the validation cohort

From: Histologic and cytomorphologic features of ALK-rearranged lung adenocarcinomas

 

Sensitivity

Specificity

PPV

NPV

 

MV model

Any SRC

≥10% SRC

MV model

Any SRC

≥10% SRC

MV model

Any SRC

≥10% SRC

MV model

Any SRC

≥10% SRC

All tumors (N=78)

0.88

0.60

0.31

0.45

0.74

0.92

0.49

0.58

0.68

0.87

0.76

0.69

Primary tumors (N=60)

0.88

0.60

0.26

0.42

0.73

0.92

0.45

0.54

0.65

0.87

0.77

0.70

Metastatic tumors (N=18)

0.88

0.75

0.44

0.55

0.90

0.90

0.61

0.86

0.75

0.85

0.82

0.68

Small biopsy specimens (N=31)

0.93

0.71

0.29

0.29

0.82

0.94

0.52

0.77

0.80

0.86

0.78

0.62

  1. Abbreviations: MV, multivariate; NPV, negative predictive value; PPV, positive predictive value; SRC, signet ring cells. Sensitivity, specificity, PPV, and NPV for all cases in the validation set as well as subset analysis for primary tumors, metastatic tumors, and small biopsy specimens are shown.
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