Figure 2 | Modern Pathology

Figure 2

From: Mitotic figure counts are significantly overestimated in resection specimens of invasive breast carcinomas

Figure 2

Proliferative index of breast carcinomas as assessed using MIB-1 immunohistochemistry in breast cancer biopsy material and resection specimen. Each line represents one of 52 invasive ductal carcinomas. MIB-1 immunohistochemistry was assessed by joint visual estimation by two observers. The left panel depicts the percentage of tumor cells labeled with MIB-1. The right panel depicts the ratio for each carcinoma of MIB-1 over the mitotic figure counts in 10 high power fields. Note that with the exception of a few cases, MIB-1 appears to be comparable in biopsy material and in resection specimen. However, the ratio of MIB-1 over mitotic figure counts is significantly reduced in resection specimen (P<0.02, paired t-test).

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