Figure 3

Genome-wide frequency plot of copy number alterations in 28 mucoepidermoid carcinomas. A total of 122 copy number alterations were detected across the genome (sex chromosomes excluded). Losses (red) were more common than gains (blue) (a). Distribution of the different copy number alterations in CRTC1–MAML2-positive (Fus +) and -negative (Fus −) tumors (b) and in low-grade (LG) and high-grade (HG) mucoepidermoid carcinomas. The number of genomic imbalances per tumor was significantly lower in fusion-positive tumors compared with fusion-negative tumors (1.5 vs 9.5; P=0.002). Similarly, LG mucoepidermoid carcinomas had significantly fewer copy number alterations per tumor compared with HG mucoepidermoid carcinomas (0.7 vs 8.6; P<0.0001). Note that the profiles of fusion-positive and LG tumors are very similar and that the profiles of fusion-negative and HG tumors are almost identical.