Table 3 Summary of treatment regimens prior and following the development of monocytosis and the clinical status of patients

From: Development of monocytosis in patients with primary myelofibrosis indicates an accelerated phase of the disease

Case

Age/Sex

Treatment

Clinical status

Cause of death

  

Pre-monocytosis

Post-monocytosis

Post-monocytosis

 

1

74/M

None

Gleevec, anagrelide, hydroxyurea, decitabine

Dead

Respiratory and renal failure

2

66/F

Thalidomide

Panibinostat

Supportive care, transfusion dependent

3

69/M

Not available

Not available

Alive

4

52/F

Lestaurtinib, thalidomide, arsenic/ara C

Stem cell transplant

Dead (acute myeloid leukemia)

Acute myeloid leukemia

5

67/M

Darbopetin alfa, danazol

Thalidomide, prednisone, decitabine, lestaurtinib arsenic/ara C, hydroxyurea, interferon

Dead

Respiratory failure

6

82/F

None

Pomalidomide, prednisone, ruxolitinib, hydroxyurea

Dead

Unknown

7

62/F

Hydroxyurea, anagrelide

Hydroxyurea, interferon

Stable disease

8

79/M

Hydroxyurea

Hydroxyurea

Dead

Unknown

9

76/M

Hydroxyurea, anagrelide

Hydroxyurea and anagrelide

Transfusion dependent

10

63/F

Interferon

Interferon

Stable disease

  1. Abbreviations: M, male; F, female.