Figure 2 | Modern Pathology

Figure 2

From: Immunohistochemistry with a mutation-specific monoclonal antibody as a screening tool for the BRAFV600E mutational status in primary cutaneous malignant melanoma

Figure 2

Cases with BRAF mutation other than V600E (case 2=a–d; case 8=e–h). (a) Direct DNA sequencing demonstrating the glutamic acid to lysine substitution (GTG to AAG). (b/f) Scanning magnification, H&E. (c/g) High power, H&E. (d/h) Immunohistochemical stain with the anti-B-Raf (V600E) antibody (brown staining seen is melanin). (e) Direct DNA sequencing demonstrating the glutamic acid to methionine substitution (GTG to ATG).

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