Table 1 Clinicopathological and FISH data of extranodal marginal zone lymphoma and diffuse large B-cell lymphoma of the thyroid, testis and breast for detection of t(11;18)(q21;q21) (t(1;14)(p22;q32), t(14;18)(q32;q21) involving IGH/MALT1 and IGH/BCL-2 and numerical aberrations of chromosomes 1, 3, 12 and 18
Patients | Sex/age | Origin | Histology | AAS | IPI | Site of relapse | Follow-up (months) | Structural and Numerical aberration |
|---|---|---|---|---|---|---|---|---|
1 | f/48 | Thyroid | EMZL | IV | 3 | Bone marrow, para-aortic and mesenteric LN | 132 (Alive) | Trisomy 18 |
2 | F/52 | Thyroid | EMZL | IE | 3 | None | 135 (AR) | Trisomy 3 |
3 | M/54 | Thyroid | EMZL | IE | 0 | None | 240 (AR) | — |
4 | F/67 | Thyroid | DLBCL | IV | Unknown | Hilar LN | 7 (DP) | Trisomy 3, 18 |
5 | F/65 | Thyroid | DLBCL | IIE | 1 | None | 130 (DI) | — |
6 | F/81 | Thyroid | DLBCL | IE | 3 | None | 1 (DI) | Trisomy 18 |
7 | M/82 | Testis | DLBCL+EMZL | IE | 1 | Pleura | 30.6 (DP) | — |
8 | M/78 | Testis | DLBCL+EMZL | IE | 1 | None | 82.8 (DI) | Tetraploidy18 |
9 | M/69 | Testis | DLBCL+EMZL | IIE | 2 | None | 50.8 (DU) | Trisomy 1, 3, 18 |
10 | M/72 | Testis | DLBCL+EMZL | IV | 3 | Bone marrow and stomach | 44.7 (DP) | Trisomy 1, 3, 18 |
11 | M/83 | Testis | DLBCL | IIE | 1 | CNS | 10.8 (DI) | T(14;18) IGH/MALT1, Trisomy 3 |
12 | M/76 | Testis | DLBCL | IIIE | 3 | None | 10.8 (DI) | Trisomy 3, 18 |
13 | M/58 | Testis | DLBCL | IIE | 1 | CNS and eyes | 12 (DP) | — |
14 | M/88 | Testis | DLBCL | IIE | 2 | Para-aortic, iliac and mediastinal LN | 2.6 (DP) | Trisomy 12, 18 |
15 | M/76 | Testis | DLBCL | IIE | 2 | 1.2 (DC) | Trisomy 18 | |
16 | F/62 | Breast | EMZL | IE | 1 | None | 134 (AR) | Trisomy 18 |
17 | F/65 | Breast | EMZL | IE | 1 | None | 74 (AR) | — |
18 | F/74 | Breast | EMZL | IIIE | 2 | Para-vertebral muscles and chest wall | 66 (AR) | Trisomy 3, 18 |
19 | F/62 | Breast | DLBCL+EMZL | IE | 1 | None | 218 (AR) | T(14;18) IGH/MALT1 |
20 | F/60 | Breast | DLBCL+EMZL | IIE | 0 | None | 153 (AR) | Trisomy 18 |
21 | F/65 | Breast | DLBCL+EMZL | IIIE | 4 | Stomach; cervical LN | 13 (DP) | — |
22 | F/53 | Breast | DLBCL+EMZL | IE | 0 | CNS | 41 (DI) | — |
23 | F/69 | Breast | DLBCL+EMZL | IE | 1 | None | 50 (AR) | Trisomy 18 |
24 | F/81 | Breast | DLBCL | IE | 3 | None | 67 (DU) | Trisomy 18 |
25 | F/65 | Breast | DLBCL | IE | 1 | Supraclavicular, mediastinal, para-aortic and iliac LN | 25 (AP) | Tetraploidy 3, 18 |
26 | F/89 | Breast | DLBCL | IV | 3 | None | 4 (DU) | Trisomy 18 |
27 | F/83 | Breast | DLBCL | IE | Unknown | None | 11 (DI) | Trisomy 11, 18 |
28 | F/56 | Breast | DLBCL | IIE | 0 | None | 101 (AR) | T(14;18) IGH/MALT1 |
29 | F/85 | Breast | DLBCL | IE | 1 | Pleura; mediastinal, suprclavicular, para-aortic LN | 11 (DP) | Trisomy 1, 3, 18 |
30 | F/73 | Breast | DLBCL | IE | Unknown | CNS | 54 (DP) | — |
