Figure 8
From: Mesothelioma with signet-ring cell features: report of 23 cases
Signet-ring cell lung adenocarcinoma. (a) The nucleus appears to be displaced toward the periphery of the cell by a large number of mucin granules of medium and low electron density. (Inset: higher magnification showing a better detail of the granules.) (b) The same case showing another signet-ring cell having an intracytoplasmic lumen and abundant mucin granules. (c) Higher magnification of a portion of a signet-ring cell in which the mucin granules seem to be aligned along the intracytoplasmic lumen and some appear to be emptying their content into the lumen. (a, × 11 000, inset, × 18 000; b, × 17 500; c, × 20 000).
