Table 3 Follicular hyperplasia vs lymphoma: special studies
From: Benign lymphadenopathies
Reactive follicular hyperplasia | Follicular lymphoma |
|---|---|
Bcl-2 negative in B cells of germinal centers | Bcl-2 positive in B cells in germinal centers (90%) |
No light chain restriction on immunostains (rare exceptions) | Light chain restriction (20% in paraffin) |
No light chain restriction on flow cytometry (rare exceptions) | Light chain restriction or absent, when gated correctly (95%) |
Ig rearrangements absent (rare exceptions) | Ig rearrangements usually detected (80%) |
Cytogenetic abnormalities infrequent, but have been described; t(14;18) absent (rare exceptions) | t(14;18) usually present (90%) |
