Figure 4

Splenic marginal zone lymphoma. (a) Predominant white pulp infiltration with interstitial red pulp disease and small red pulp nodules. The white pulp contains a regressed germinal centre; H&E. (b) Central germinal centres may reactive; H&E. (c) The infiltrate around the residual follicles has an inner zone of small cells and an outer zone of cells with more abundant cytoplasm; H&E. (d) Bone marrow infiltration shows an interstitial population of small cells with an intrasinusoidal component; CD20.