Figure 1 | Modern Pathology

Figure 1

From: Distinct profile of driver mutations and clinical features in immunomarker-defined subsets of pulmonary large-cell carcinoma

Figure 1

Immunohistochemistry-defined subtypes of large-cell carcinoma. (a) Coexpression profiles of TTF-1 and ΔNp63 (p40). #TTF-1 and ΔNp63 labeled distinct cell populations. (b) Pie chart showing TTF-1/ΔNp63 -based subtypes of large-cell carcinoma. (c) Examples of microscopic findings. H&E shows morphologically indistinguishable non-small-cell carcinomas, all growing as entirely solid nests or sheets of tumor cells with no evidence of either glandular or squamous differentiation. Despite the lack of differentiating morphology, marker profiles provide evidence of submorphologic differentiation as adenocarcinoma (A−C) or squamous cell carcinoma (D−F); (G−I) illustrates a marker-null large-cell carcinoma. Benign pneumocytes (TTF-1+) are seen at the tumor periphery (black arrowheads) or entrapped within the tumor (blue arrowheads). Insets in a, d and g show higher-power images. Abbreviations: ADC, adenocarcinoma; AD-SQC, adenosquamous carcinoma; LCC, large-cell carcinoma; SQCC, squamous cell carcinoma.

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