Table 2 Summary of clinical and pathologic findings
Case | Sex/age | Type of specimen | Location | Light microscopy (% pleomorphic cell component) | Treatment | Follow-up (months) |
|---|---|---|---|---|---|---|
1 | M/72 | Biopsy | Rt. pleura | Mixture of discohesive, often multi-nucleated, cells that exhibit a great variation in their size and shape (100%). Sometimes the pleomorphic cells appeared to be lining irregular spaces or poorly formed papillae. Numerous, often atypical, mitoses were present. | Chemotherapy | INA |
2 | M/71 | Pneumonectomy | Lt. pleura | About 25% of the tumor was composed of pleomorphic epithelioid cells that were often multinucleated. | Pneumonectomy+radiotherapy | DOD (4) |
3 | M/56 | Biopsy | Peritoneum | Diffuse proliferation of pleomorphic epithelioid cells, some of which contained multiple nuclei (100%). Numerous mitoses, many atypical, were seen. | INA | INA |
4 | M/74 | Pneumonectomy | Lt. pleura | About 80% of the tumor composed of large, often multinucleated, epithelioid cells arranged in irregular, solid nests. High mitotic activity, prominent lymphatic invasion and extensive necrosis. | Pneumonectomy+radiotherapy | DOD (17) |
5 | M/62 | Biopsy | Rt. pleura | Diffuse proliferation of discohesive cells with abundant cytoplasm, many of which were multinucleated (100%). Mitoses, including atypical mitoses, were numerous. | Chemotherapy | INA |
6 | M/67 | Pneumonectomy | Lt. pleura | About 30% of the tumor was composed of a diffuse proliferation of pleomorphic epithelioid cells, some of which were multinucleated. Numerous mitoses, including some that were atypical, were present. | Pneumonectomy | DOD (3) |
7 | M/64 | Pneumonectomy | Rt. pleura | About 25% of the tumor was composed of pleomorphic epithelioid cells that were often multinucleated. | Pneumonectomy+radiotherapy | DOD (4) |
8 | M/73 | Pneumonectomy | Rt. pleura | About 15% of the tumor was composed of pleomorphic epithelioid cells, some of which were multinucleated. | Chemotherapy+pneumonectomy | DOD (6) |
9 | M/67 | Pneumonectomy | Lt. pleura | About 20% of the tumor was composed of pleomorphic epithelioid cells, some of which were multinucleated. | Pneumonectomy+radiotherapy | DOD (10) |
10 | M/61 | Pneumonectomy | Rt. pleura | Diffuse proliferation of pleomorphic epithelioid cells, many of which were multi-nucleated (100%). On occasion, the pleomorphic cells appeared to be lining poorly formed tubular-like structures. Prominent lymphatic invasion present. | Pneumonectomy | AWD (3) |
