Figure 1 | Modern Pathology

Figure 1

From: Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors

Figure 1

ATRX and DAXX immunolabeling and telomere-specific FISH in a MEN-1 microadenoma (a–d) and in a 3.5-cm MEN-1 pancreatic neuroendocrine tumor with a DAXX defect and the alternative lengthening of the telomeres phenotype (e–h). H&E (a, e), ATRX (b, f), DAXX with retained nuclear expression (c) and loss of nuclear expression (wih entrapped non-neoplastic duct) (g), telomere-specific FISH (d, h). Asterisks highlight nuclei with normal telomere-specific FISH signals. Arrows highlight alternative lengthening of telomeres-specific foci of telomeric DNA (DAPI nuclear counterstain). All images were taken at × 400 magnification.

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