Table 1 DLC1 methylation and protein levels in extramammary Paget’s disease

From: Correlation of DLC1 gene methylation with oncogenic PIK3CA mutations in extramammary Paget's disease

 

Total

Methylation level a

P-valueb

Protein level c

P-valueb

  

0–1%

1–100%

 

Normal

Reduced

 

Case, n

132

81

51

—

89

43

—

Age, years

 >70

60

26

31

0.002

34

26

0.016

 ≤70

72

52

20

—

55

17

—

Sex

 Male

110

67

43

0.729

78

38

0.352

 Female

22

13

7

—

17

5

—

Invasion status

 Invasive

38

21

17

0.360

23

15

0.282

 In situ

94

60

34

—

66

28

—

  1. Abbreviations: DLC1, deleted in liver cancer 1; IHC, immunohistochemistry.
  2. a Detected by methylation-sensitive, high-resolution melting analysis.
  3. b Determined by χ2-test.
  4. c Detected by IHC.
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