Figure 1 | Modern Pathology

Figure 1

From: Expression of the promyelocytic leukemia zinc-finger in T-lymphoblastic lymphoma and leukemia has strong implications for their cellular origin and greater association with initial bone marrow involvement

Figure 1

Immunohistochemical expression of PLZF in lymphoid tissue and neoplasms. PLZF was immunostained in the nucleus of lymphoid cells. (a) In a fetal thymus at gestational age 22 weeks, some scattered PLZF (+) small to medium-sized cells were observed. In adult thymus (b, left) and lymph node (b, right), only a few small lymphoid cells were PLZF (+). T-LBL/ALLs showed variable expression of PLZF (c–f). Some reveal diffuse strong positivity in the tumor cells (c); others have weak-to-moderate intensity in some of the tumor cells (d); still others are completely negative for PLZF (f). (e) Occasionally, PLZF immunostained only in a small portion of tumor cells in T-LBL/ALL. (Original magnification, × 400 in all).

Back to article page