Figure 1
Representative photographs of immunohistochemical features of p53, cyclin D1, EGFR and VEGF in normal esophageal epithelia and superficial esophageal squamous cell carcinoma. P53 is negative in normal epithelia (a) and weakly (b) or strongly positive (c) in superficial esophageal squamous cell carcinoma. Cyclin D1 positivity is found only in the suprabasal cells of normal epithelia (d); it is weakly (e) or strongly (f) positive in superficial esophageal squamous cell carcinoma. EGFR staining can be very weak in the basal and suprabasal layers of normal epithelia (g); in superficial esophageal squamous cell carcinoma it is weakly (h) or strongly (i) positive, with the positive signal localized in the membrane of the cancer cells. VEGF staining can be very weak in the basal and suprabasal layers of normal epithelia (j); it is weakly (k) or strongly (l) positive in superficial esophageal squamous cell carcinoma (original magnification, × 200).
