Table 1 Summary of clinical, endoscopic and histopathological characteristics of the total 271 patients, and the total 208 patients with submucosal invasion thickness ≥250 μm, and the 170 tissue microarray patients with submucosal invasion thickness ≥250 μm
Characteristics | Total cases (n=271), no. (%) | Cases with submucosal invasion thickness ≥250 μm (n=208), no. (%) | Tissue microarray cases with submucosal invasion thickness ≥250 μm (n=170), no. (%) | Pa | Pb |
|---|---|---|---|---|---|
Clinical variables | |||||
Sex | |||||
Male | 197 (73) | 152 (73) | 124 (73) | 0.955 | 0.976 |
Female | 74 (27) | 56 (27) | 46 (27) | ||
Age | |||||
<60 years | 167 (62) | 127 (61) | 106 (62) | 0.878 | 0.797 |
≥60 years | 104 (38) | 81 (39) | 64 (38) | ||
Symptoms | |||||
No symptoms | 14 (5) | 8 (4) | 5 (3) | 0.263 | 0.631 |
Others | 257 (95) | 200 (96) | 165 (97) | ||
Endoscopic variables | |||||
Tumor location | |||||
Cervical | 2 (1) | 2 (1) | 2 (1) | 0.756 | 0.995 |
Upper thoracic | 43 (16) | 39 (18) | 33 (19) | ||
Middle thoracic | 187 (69) | 139 (67) | 112 (66) | ||
Lower thoracic | 39 (14) | 28 (14) | 23 (14) | ||
Tumor size (measured endoscopically) | |||||
<2 cm | 70 (26) | 44 (21) | 37 (22) | 0.332 | 0.886 |
≥2 cm | 201 (74) | 164 (79) | 133 (78) | ||
Macroscopic type | |||||
Erosive | 85 (31) | 45 (22) | 32 (19) | 0.071 | 0.956 |
Papillary | 32 (12) | 26 (13) | 22 (13) | ||
Plaque like | 120 (44) | 106 (51) | 92 (54) | ||
Ulcerative | 15 (6) | 14 (7) | 10 (6) | ||
Intraluminal mass | 19 (7) | 17 (8) | 14 (8) | ||
Standard histopathological variables | |||||
Invasion depth level | |||||
m2 | 22 (8) | NA | NA | <0.001 | 0.875 |
m3 | 30 (11) | NA | NA | ||
sm1 | 23 (9) | 12 (6) | 10 (6) | ||
sm2 | 55 (20) | 55 (26) | 41 (24) | ||
sm3 | 141 (52) | 141 (68) | 119 (70) | ||
Degree of differentiation | |||||
Well | 49 (18) | 42 (20) | 36 (21) | 0.650 | 0.934 |
Moderate | 104 (38) | 77 (37) | 68 (40) | ||
Poor | 80 (30) | 57 (27) | 40 (24) | ||
Basaloid | 25 (9) | 24 (12) | 19 (11) | ||
Sarcomatoid | 13 (5) | 8 (4) | 7 (4) | ||
Angiolymphatic invasion | |||||
No | 220 (81) | 161 (77) | 132 (78) | 0.368 | 0.955 |
Yes | 51 (19) | 47 (23) | 38 (22) | ||
Multicentric invasive lesions | |||||
No | 248 (92) | 194 (93) | 160 (94) | 0.312 | 0.736 |
Yes | 23 (8) | 14 (7) | 10 (6) | ||
Glandular involvement by high-grade dysplasia/carcinoma-in-situ | |||||
No | 198 (73) | 156 (75) | 129 (76) | 0.510 | 0.843 |
Yes | 73 (27) | 52 (25) | 41 (24) | ||
Measured histopathological variables | |||||
Tumor thickness | |||||
<3000 μm | 98 (36) | 46 (22) | 34 (20) | <0.001 | 0.616 |
≥3000 μm | 173 (64) | 162 (78) | 136 (80) | ||
Submucosal invasion thickness | |||||
<2000 μm | 156 (58) | 93 (45) | 71 (42) | 0.005 | 0.565 |
≥2000 μm | 115 (42) | 115 (55) | 99 (58) | ||
Diameter of largest invasive lesion | |||||
<2 cm | 172 (63) | 112 (54) | 90 (53) | 0.034 | 0.861 |
≥2 cm | 99 (37) | 96 (46) | 80 (47) | ||
Lymph node metastasis | |||||
No | 218 (80) | 157 (75) | 123 (72) | 0.048 | 0.490 |
Yes | 53 (20) | 51 (25) | 47 (28) | ||
Immunohistochemial staining | |||||
P53 | |||||
− | NA | NA | 76 (46) | NA | NA |
+ | NA | NA | 41 (25) | ||
++ | NA | NA | 47 (29) | ||
Cyclin D1 | |||||
− | NA | NA | 51 (31) | NA | NA |
+ | NA | NA | 47 (29) | ||
++ | NA | NA | 64 (40) | ||
EGFR | |||||
− | NA | NA | 59 (36) | NA | NA |
+ | NA | NA | 53 (32) | ||
++ | NA | NA | 52 (32) | ||
VEGF | |||||
− | NA | NA | 51 (31) | NA | NA |
+ | NA | NA | 45 (28) | ||
++ | NA | NA | 66 (41) | ||
