Table 3 Relationships between clinical and endoscopic variables, standard and measured histopathological variables, immunohistochemical staining and lymph node metastasis in the total 271 patients
Parameters | Total | Lymph node metastasis (%) | Univariate logistic regression | |||
|---|---|---|---|---|---|---|
Odds ratio | 95% CI | Global P | P- for-trend | |||
Clinical variables | ||||||
Sex | ||||||
Male | 197 | 43 (22) | 1 | |||
Female | 74 | 10 (14) | 0.560 | 0.265–1.181 | 0.128 | |
Age | ||||||
<60 | 167 | 36 (22) | 1 | |||
≥60 | 104 | 17 (16) | 0.711 | 0.376–1.345 | 0.294 | |
Symptoms | ||||||
No | 14 | 0 | 1 | |||
Yes | 257 | 53 (21) | 4.197 × 108 | 0–∞ | 0.999 | |
Endoscopic variables | ||||||
Tumor location | ||||||
Cervical | 2 | 0 | 0 | 0–∞ | 0.999 | |
Upper thoracic | 43 | 8 (19) | 0.993 | 0.424–2.326 | 0.986 | |
Middle thoracic | 187 | 35 (19) | 1 | |||
Lower thoracic | 39 | 10 (26) | 1.498 | 0.668–3.357 | 0.327 | |
Tumor size (measured endoscopically) | ||||||
<2 cm | 70 | 8 (11) | 1 | |||
≥2 cm | 201 | 45 (22) | 2.236 | 0.997–5.013 | 0.051 | |
Macroscopic type | ||||||
Erosive | 85 | 7 (8) | 1 | |||
Papillary | 32 | 4 (13) | 1.592 | 0.433–5.853 | 0.484 | |
Plaque like | 120 | 31 (26) | 3.881 | 1.618–9.308 | 0.002 | |
Ulcerative | 15 | 5 (33) | 5.571 | 1.484–20.920 | 0.011 | |
Intraluminal mass | 19 | 6 (32) | 5.143 | 1.491–17.744 | 0.010 | |
Standard histopathological variables | ||||||
Invasion depth level | ||||||
m2 | 22 | 0 | 1.903 | 1.334–2.716 | <0.001 | |
m3 | 30 | 2 (7) | ||||
sm1 | 23 | 4 (17) | ||||
sm2 | 55 | 7 (13) | ||||
sm3 | 141 | 40 (28) | ||||
Degree of differentiation | ||||||
Well | 49 | 4 (8) | 1 | |||
Moderate | 104 | 21 (20) | 2.846 | 0.920–8.804 | 0.069 | |
Poor | 80 | 19 (24) | 3.504 | 1.115–11.011 | 0.032 | |
Basaloid | 25 | 5 (20) | 2.812 | 0.682–11.593 | 0.152 | |
Sarcomatoid | 13 | 4 (31) | 5.000 | 1.051–23.789 | 0.043 | |
Angiolymphatic invasion | ||||||
No | 220 | 34 (16) | 1 | |||
Yes | 51 | 19 (37) | 3.248 | 1.654–6.381 | 0.001 | |
Multicentric invasive lesions | ||||||
No | 248 | 47 (19) | 1 | |||
Yes | 23 | 6 (26) | 1.509 | 0.565–4.035 | 0.412 | |
Glandular involvement by high-grade dysplasia/carcinoma-in-situ | ||||||
No | 198 | 37 (19) | 1 | |||
Yes | 73 | 16 (22) | 1.221 | 0.632–2.362 | 0.552 | |
Measured histopathological variables | ||||||
Tumor thickness | ||||||
<3000 μm | 98 | 6 (6) | 1 | |||
≥3000 μm | 173 | 47 (27) | 5.720 | 2.346–13.944 | <0.001 | |
Submucosal invasion thickness | ||||||
<1000 μm | 101 | 8 (8) | 1 | |||
≥1000 μm | 170 | 45 (26) | 4.107 | 1.848–9.128 | <0.001 | |
Diameter of the largest invasive lesion | ||||||
<2 cm | 172 | 27 (16) | 1 | |||
≥2 cm | 99 | 26 (26) | 1.913 | 1.042–3.512 | 0.036 | |
Immunohistochemical staining a | ||||||
P53 | ||||||
− | 81 | 20 (25) | 0.987 | 0.672–1.449 | 0.947 | |
+ | 47 | 16 (34) | ||||
++ | 56 | 13 (23) | ||||
Cyclin D1 | ||||||
− | 54 | 12 (22) | 1.125 | 0.751–1.684 | 0.569 | |
+ | 58 | 17 (29) | ||||
++ | 70 | 19 (27) | ||||
EGFR | ||||||
− | 69 | 14 (20) | 1.670 | 1.106–2.523 | 0.015 | |
+ | 57 | 10 (18) | ||||
++ | 57 | 23 (40) | ||||
VEGF | ||||||
− | 64 | 8 (13) | 2.283 | 1.485–3.509 | <0.001 | |
+ | 49 | 12 (24) | ||||
++ | 68 | 29 (43) | ||||
