Table 2 Correlation between androgen receptor immunohistochemical detection and clinicopathological parameters (N=699)
Clinicopathological parameters | Total | AR-negative expression | AR-positive expression | P-value |
|---|---|---|---|---|
Age (years) (mean 53, median 52, range 25–89) | 0.221 | |||
<Mean age | 374 | 239 (64%) | 135 (36%) | |
≥Mean age | 325 | 193 (59%) | 132 (41%) | |
Ethnicity | 0.967 | |||
Chinese | 583 | 360 (62%) | 223 (38%) | |
Malay | 58 | 36 (62%) | 22 (38%) | |
Indian | 37 | 24 (65%) | 13 (35%) | |
Others | 21 | 12 (57%) | 9 (43%) | |
Tumor size (mm) (mean 36, median 30, range 9–200) | 0.875 | |||
≤20 | 196 | 120 (61%) | 76 (39%) | |
>20 | 480 | 297 (62%) | 183 (38%) | |
Histologic grade | 0.002a | |||
1 | 20 | 10 (50%) | 10 (50%) | |
2 | 136 | 69 (51%) | 67 (49%) | |
3 | 538 | 350 (60%) | 188 (40%) | |
Tubule formation | 0.072 | |||
>75% tubule formation | 16 | 10 (63%) | 6 (37%) | |
≥10–75% tubule formation | 113 | 59 (52%) | 54 (48%) | |
<10% tubule formation | 570 | 363 (64%) | 207 (36%) | |
Nuclear pleomorphism | 0.114 | |||
Mild | 7 | 3 (43%) | 4 (57%) | |
Moderate | 219 | 128 (58%) | 91 (42%) | |
Marked | 473 | 301 (64%) | 172 (36%) | |
Mitotic score (field diameter 0.5 mm) | 0.009a | |||
1 | 58 | 28 (48%) | 30 (52%) | |
2 | 154 | 90 (58%) | 64 (42%) | |
3 | 481 | 311 (65%) | 170 (35%) | |
Histologic subtype | 0.611 | |||
IDC | 631 | 392 (62%) | 239 (38%) | |
Non-IDC | 68 | 40 (59%) | 28 (41%) | |
Associated DCIS | 0.216 | |||
Absent | 209 | 136 (65%) | 73 (35%) | |
Low nuclear grade | 8 | 5 (63%) | 3 (37%) | |
Intermediate nuclear grade | 70 | 38 (54%) | 32 (46%) | |
High nuclear grade | 242 | 145 (60%) | 97 (40%) | |
Lymphovascular invasion | 0.302 | |||
Absent | 486 | 295 (61%) | 191 (39%) | |
Present | 205 | 133 (65%) | 72 (35%) | |
Axillary lymph node status | 0.936 | |||
pN0 | 3 | 3 (100%) | 0 (0%) | |
pN1 | 335 | 211 (63%) | 124 (37%) | |
pN2 | 140 | 83 (59%) | 57 (41%) | |
pN3 | 138 | 89 (65%) | 49 (35%) | |
Microscopic borders | 0.032a | |||
Infiltrating | 589 | 354 (60%) | 235 (40%) | |
Pushing | 110 | 78 (71%) | 32 (29%) | |
Growth pattern | 0.436 | |||
Trabecular | 322 | 204 (63%) | 118 (37%) | |
Syncytial | 377 | 228 (61%) | 149 (39%) | |
Basal-like phenotype | 0.234 | |||
No | 106 | 71 (67%) | 35 (33%) | |
Yes | 593 | 361 (61%) | 232 (39%) |
