Figure 5
From: Immunohistochemical detection of ROS1 is useful for identifying ROS1 rearrangements in lung cancers
One case showed ROS1 rearrangement determined using FISH (a, arrows indicate rearranged signals), although no ROS1 fusion transcript was amplified using multiplex RT-PCR. ROS1 immunostaining was almost negative (b). The tumor harbored an EGFR exon 19 deletion and diffusely expressed mutant EGFR as detected using immunohistochemistry (c).
