Figure 2
From: Retinoblastoma gene mutations detected by whole exome sequencing of Merkel cell carcinoma
Fluorescence in situ hybridization confirms loss of RB1 in the only two cases of Merkel cell carcinoma as discovered by whole exome sequencing. (a) One case is Merkel cell polyomavirus-negative (case 21). (b) The other case is polyomavirus-positive (case 27). Normal RB1 copy number was observed in the other cases (not shown). Red=RB1; green=13q14.
