Figure 4
From: Retinoblastoma gene mutations detected by whole exome sequencing of Merkel cell carcinoma
Phosphorylated-retinoblastoma protein immunoreactivity is absent in all Merkel cell carcinoma cases, including those with pan-retinoblastoma staining. (a) Case 24, (b) Case 06, (c) Case 27, (d) Case 39, (e) Case 18, (f) Case 33, (g) Case 29, and (h) Case 21. Internal positive controls for phosphorylated-retinoblastoma are seen in few stromal and lymph node lymphocytes. All images were taken at × 200 original magnification.
