Figure 4
From: GNAS mutational analysis in differentiating fibrous dysplasia and ossifying fibroma of the jaw
GNAS mutational analysis in one case with overlapping clinicopathological characteristics of fibrous dysplasia and ossifying fibroma. (a) The panoramic radiograph revealed an expansion of ramus and corpus of the left mandible with a ‘ground-glass’ appearance. Cystic change with a sclerotic margin could be seen in the corpus. (b) Histologic features of the lesion: the low-power view ( × 40) showing small, round and disconnected bone lying within a cellular fibrous stroma, which was abundant compared with the area of the bone; osteoblasts could be seen around the bone surface as revealed in the high-power view (inset, × 200). (c) The sequence of polymerase chain reaction (PCR)-amplified product showed a mutation at the Arg201 codon (arrow), CGT>CAT (p.R201H).
