Figure 1

Chromophobe hepatocellular carcinomas with abrupt anaplasia. Two separate cases are illustrated, with the first case in the left column of panels and the second in the right column of panels. Pseudocysts are evident in both cases (a, b; H&E, original magnification × 40). The cytoplasm of the tumor cells have a ‘chromophobe appearance’ where the staining qualities of the tumor cytoplasm are not as deep as seen in typical hepatocellular carcinomas (c, d; H&E, original magnification × 100). The cytoplasm can be either slightly eosinophilic (c) or basophilic (d). The nuclei of most tumor cells are small and round with small inconspicuous nucleoli. However, cells in small irregularly distributed clusters show marked nuclear anaplasia (e, f; H&E, original magnification × 160).