Figure 2

Mimics of chromophobe hepatocellular carcinomas with abrupt anaplasia. Pseudocysts are a regular feature of chromophobe hepatocellular carcinomas with abrupt anaplasia, but most cases of hepatocellular carcinoma with pseudocysts will not be chromophobe hepatocellular carcinomas with abrupt anaplasia. (a) A hepatocellular carcinoma with pseudocysts that is not a chromophobe hepatocellular carcinoma with abrupt anaplasia (H&E, original magnification × 64). (b) A hepatocellular carcinoma with cytoplasmic findings that somewhat mimic the chromophobe cytoplasm of chromophobe hepatocellular carcinomas with abrupt anaplasia, but this tumor lacks pseudocysts, sudden anaplasia, and has prominent nucleoli, all features inconsistent with chromophobe hepatocellular carcinoma with abrupt anaplasia (H&E, original magnification × 160). (c) A clear cell hepatocellular carcinoma with areas of marked anaplasia. This morphological pattern can be a strong mimic of chromophobe hepatocellular carcinomas with abrupt anaplasia, but the nuclear changes in most clear cell hepatocellular carcinoma (irregular vesiculated nuclei with prominent nucleoli) are sufficient to distinguish this mimic from chromophobe hepatocellular carcinomas with abrupt anaplasia (H&E, original magnification × 160).