Figure 3
Examples of the SMARCB1-deficient monomorphic subtype. (a) Small to medium sized monotonous rhabdoid cells in pseudoalveolar pattern. (b) Another case showed prominent neutrophilia and focal gland formation (upper left). (c) Epithelioid large cell pattern mimicking angiosarcoma. (d) Compact sheets of large cells with frequent rhabdoid inclusions mimicking proximal-type epithelioid sarcoma. (e) Characteristic paranuclear cytokeratin expression (KL1). Inset: loss of pancytokeratin in another case with focal expression in gland-like areas. (f) Complete loss of nuclear SMARCB1 expression (main image: same case as in a with retained expression in endothelial and stromal cells; inset: same case as in b, with prominent nuclear staining of neutrophils and stromal cells).
