Table 2 Clinicopathological and molecular features of undifferentiated rhabdoid pancreatic carcinomas, own series (n=14)
No | Pattern | Age (years)/sex | Site | Size (cm) | Treatment | MTS | Outcome | Glandular component | KRAS mutation status | KRAS FISH | SMARCB1 IHC |
|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Pleomorphic giant cell | 68/F | NS | 6 | Surgery | Lymph nodes extensive | Abdominal recurrence, DOD 2 mo | PanIN3 | p.Gly12Val | Normal | Intact |
2 | Pleomorphic giant cell | 62/M | Body | 6.7 | Biopsy, palliative CT | Liver | Alive, 6 mo | Focus of WD-ADCA | WT | Normal | Intact |
3 | Pleomorphic giant cell | 58/F | Tail | NS | Biopsy | Liver, peritoneum | DOD, 2 days | No (only biopsy) | p.Gly12Val | Normal | Intact |
4 | Pleomorphic giant cell | 67/M | Head | 3 | Autopsy | Liver | DOD, initially | ADCA (<5%) | p.Gly12Asp | Amplified | Intact |
5 | Pleomorphic giant cell, myxoid pseudomucinous | 71/M | Head | 6 | Surgery | No | NA | PanIN1 | NR | Normal | Intact |
6 | Pleomorphic giant cell, melanoma-like | 46/M | Head | 3 | Surgery | Lymph nodes | NA | No | NR | Polysomy (trisomy) | Intact |
7 | Pleomorphic giant cell, 5% spindle sarcomatous | 96/F | Tail | 6 | Autopsy | Liver | DOD, initially | ADCA <2% | p.Gly12Asp | Amplified | Intact |
8 | Pleomorphic giant cell | 63/F | Head | 6 | Surgery | Lymph nodes | NA | No | p.Gln61His | Amplified | Intact |
9 | Pleomorphic giant cell, myxoid stroma | 49/F | Head | 11 | Surgery | Lung | NA | No | NR | Amplified | Intact |
10 | Pleomorphic giant cell | 81/F | Head | 10 | Autopsy | Peritoneum, liver | DOD, initially | No | WT | NR | Intact |
11 | Monomorphic anaplastic | 76/M | Head | 5 | Surgery | NS | DOD, 1 mo | No | WT | Normal | Complete loss |
12 | Monomorphic anaplastic angiosarcoma-like | 44/F | Head | 6 | Surgery | NS | NA | Yes, minimal | p.Gly12Asp | Amplified | Complete loss |
13 | Monomorphic small cell pseudopapillary | 72/M | Head | 4 | Surgery | Lymph nodes, liver | Died post-operative | No | WT | Normal | Complete loss |
14 | Monomorphic anaplastic, prominent granulocytes | 61/M | Tail | 5 | Surgery | Intra-abdominal, stomach | NA | No | WT | Normal | Complete loss |
