Figure 4 | Modern Pathology

Figure 4

From: Renal cell carcinoma with angioleiomyoma-like stroma: clinicopathological, immunohistochemical, and molecular features supporting classification as a distinct entity

Figure 4

The stroma of renal cell carcinomas with angioleiomyoma-like stroma characteristically showed diffuse, strong labeling with antibody to smooth muscle actin (a), although reactivity for desmin was more variable and often focal (b). Labeling for caldesmon (c) was typically strong and diffuse, supporting the morphological impression of smooth muscle differentiation. Trichrome stain similarly showed a mixture of collagen and smooth muscle in the stroma (d). Fluorescence in situ hybridization uniformly showed no deletion of chromosome 3p in either the epithelial (e) or stromal (f) component.

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