Table 2 Immunohistochemical staining characteristics of renal cell carcinomas with angioleiomyoma-like stroma
Tumor | CAIX % (epithelium) | CAIX pattern (epithelium) | CK7 (epithelium) | CD10 (epithelium) | AMACR | SMA (stroma) | Desmin (stroma) | Caldesmon (stroma) | Vimentin | 34βE12 (epithelium) | PAX8 | HMB45 | Melan-A | Cathepsin K | TFE3 | CD34 | Other |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 100% | M, focal CS | 90% | 15% | — | 3+ | 1+ | 3+ | +ES | 5% | 2+ E | — | — | 1+ S | — | Dot-like | MITF− |
2 | NA | NA | NA | NA | NA | 2+ | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | ER and PR− |
3 | 40% | M, focal CS | 100% | 30% | Weak, E | 3+ | 1+ | 3+ | +ES | 90% | 3+ E | — | — | 1+ S | — | Dot-like | p63− |
4 | 65% | CS | 80% | 50% | — | 3+ | 2+ | 3+ | +ES | 40% | 3+ E | — | — | 1+ S | — | Dot-like | CD117− |
5 | 100% | CS | 100% | 30% | — | 3+ | 2+ | 3+ | +ES | 80% | 3+ E | — | — | 1+ S | — | Dot-like | |
6 | 95% | CS | 75% | 80% | Weak, E | 3+ | 2+ | 3+ | NA | 65% | 2+ E | — | — | — | — | Dot-like | p63, ER, PR− |
7 | 100% | M | 95% | 90% | 1+ S | 3+ | 3+ | 3+ | +ES | 50% | 3+ E | — | — | — | — | Dot-like | ER and PR focal in peripheral stroma |
8 | 95% | M, focal CS | 75% | 25% | — | 3+ | — | 3+ | +ES | 40% | 2+ E | — | — | 1+ S | — | Dot-like | |
9 | 60% | M | 50% | 30% | NA | 3+ | 1+ | NA | +S | NA | NA | — | — | NA | NA | Dot-like, focal | AE1/3+65% epithelium, ER−, PR focal in peripheral stroma |
10 | 100% | M | 95% | 50% | — | 3+ | 1+ | 3+ | +ES | 80% | 3+ E | — | — | 1+ S | — | Dot-like | |
11 | 95% | M, focal CS | 95% | 40% | 5% E | 3+ | 1+ | 2+ | +ES | 60% | 3+ E | — | — | — | — | Dot-like | |
12 | 100% | M, focal CS | 75% | 50% | — | 3+ | 1+ | 2+ | +ES | 20% | 3+ E | — | — | 1+ S | — | Dot-like |
