Table 3 Differential diagnosis of plasma cell neoplasms with paraneoplastic manifestations12, 13, 14, 15
| Â | Clonal PCs | Light chain | Heavy chain | Ht | WBC | Epo | Other symptoms |
|---|---|---|---|---|---|---|---|
TEMPI | 5% | κ > λ | IgG >> IgA | ↑ | nl | ↑↑ | Telengiectasias, perinephric fluid, intrapulmonary shunting |
POEMS | <10% | λ >> κ | IgG >> IgA | ↑/nl | nl | ↓ | Neuropathy, organomegaly, endocrinopathy, skin pigment and hair changes |
Schnitzler | 5% | κ > λ | IgM | ↓ | ↑ | ? | Chronic urticaria, Angioedema, arthralgia, bone lesions, leukocytosis, organomegaly |
