Table 3 Distribution of women with ovarian carcinoma according to matrix metalloproteinase-14 (MMP-14) immunostaining (mean cell number of the highest intensity (digital image analysis), average H-score (digital image analysis), intensity (visual)), and standard prognostic factors (n=170)
Mean cell number of the highest intensity | Average H-score | Maximal intensity (visual) | |||||||
|---|---|---|---|---|---|---|---|---|---|
Q1–Q3 | Q4 | P | Q1–Q3 | Q4 | P | 0 or 1 | 2 or 3 | P | |
n/128 (%) | n/42 (%) | n/127 (%) | n/43 (%) | n/98 (%) | n/62 (%) | ||||
Age group (years) | |||||||||
<50 | 26 (20) | 10 (24) | 0.7 | 24 (19) | 12 (28) | 0.17 | 18 (18) | 18 (29) | 0.2 |
50–59 | 35 (27) | 13 (31) | 35 (28) | 13 (30) | 29 (30) | 16 (26) | |||
60–69 | 34 (27) | 12 (29) | 33 (26) | 13 (30) | 25 (26) | 19 (31) | |||
≥70 | 33 (26) | 7 (17) | 35 (27) | 5 (12) | 26 (27) | 9 (15) | |||
FIGO stage | |||||||||
I–II | 28 (22) | 19 (45) | 0.003 | 28 (22) | 19 (44) | 0.005 | 16 (16) | 31 (50) | <0.0001 |
III–IV | 100 (78) | 23 (55) | 99 (78) | 24 (56) | 82 (84) | 31 (50) | |||
Histology | |||||||||
Serous | 97 (76) | 21 (50) | 0.001 | 101 (80) | 17 (40) | <0.0001 | 78 (80) | 30 (48) | <0.0001 |
Others | 31 (24) | 21 (50) | 26 (21) | 26 (61) | 20 (20) | 32 (52) | |||
Grade | |||||||||
Low | 18 (14) | 10 (24) | 0.1 | 19 (15) | 9 (21) | 0.36 | 15 (15) | 10 (16) | 0.9 |
High | 110 (86) | 32 (76) | 108 (85) | 34 (79) | 83 (85) | 52 (84) | |||
Preoperative CA-125, quartiles (U/ml) | |||||||||
0–151 | 22 (17) | 14 (33) | 0.01 | 20 (16) | 16 (37) | 0.003 | 14 (14) | 21 (34) | 0.03 |
152–441 | 36 (28) | 7 (17) | 35 (28) | 8 (19) | 28 (29) | 12 (19) | |||
442–1179 | 37 (29) | 5 (12) | 38 (30) | 4 (9) | 26 (27) | 12 (19) | |||
≥1180 | 33 (26) | 16 (38) | 34 (27) | 15 (35) | 30 (31) | 17 (27) | |||
