Table 4 Adjusted hazard ratios of death and progression of ovarian carcinoma and their 95% confidence intervals associated with the percentage of matrix metalloproteinase-14 (MMP-14)-positive cells (visual) and positive area (digital image analysis)
Death | Progression | |||||||
|---|---|---|---|---|---|---|---|---|
Crude hazard ratios (95% confidence interval) | P | Adjusted hazard ratios a (95% confidence interval) | P | Crude hazard ratios (95% confidence interval) | P | Adjusted hazard ratios a (95% confidence interval) | P | |
Percent of MMP-14-positive cells, visual scoring (n=160) | ||||||||
>40 | 0.52 (0.24–1.13) | 0.10 | 1.08 (0.47–2.49) | 0.86 | 0.39 (0.18–0.82) | 0.01 | 0.88 (0.39–2.00) | 0.76 |
21–40 | 0.91 (0.55–1.52) | 0.72 | 1.17 (0.66–2.07) | 0.59 | 0.67 (0.41–1.09) | 0.10 | 1.00 (0.59–1.69) | 0.98 |
1–20 | 0.93 (0.56–1.54) | 0.78 | 1.07 (0.64–1.79) | 0.79 | 0.80 (0.50–1.27) | 0.34 | 0.94 (0.58–1.52) | 0.80 |
0 | 1 | — | 1 | — | 1 | — | 1 | — |
Percent of MMP-14-positive area, digital image analysis, per quartile (n=170) | ||||||||
4th | 0.57 (0.32–1.00) | 0.05 | 0.83 (0.46–1.52) | 0.55 | 0.48 (0.28–0.82) | 0.008 | 0.73 (0.41–1.29) | 0.28 |
3rd | 0.90 (0.53–1.54) | 0.71 | 0.91 (0.53–1.58) | 0.75 | 0.77 (0.47–1.26) | 0.30 | 0.85 (0.51–1.41) | 0.52 |
2nd | 0.88 (0.51–1.50) | 0.63 | 0.8 (0.47–1.39) | 0.45 | 0.89 (0.55–1.45) | 0.64 | 0.83 (0.51–1.36) | 0.46 |
1st | 1 | — | 1 | — | 1 | — | 1 | — |
