Figure 2 | Modern Pathology

Figure 2

From: A novel immunohistochemical classifier to distinguish Hodgkin lymphoma from ALK anaplastic large cell lymphoma

Figure 2Figure 2

Immunhistochemical stainings differentiating classical Hodgkin lymphoma and anaplastic large cell lymphoma. (a and b) CD83; (c and d) MDC/CCL22; (e and f) STAT3; (g and h) TUBB2B; (i and j) CAPN2. (a, c, e and g) Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma show expression of the respective immunohistochemical markers. (b, d, f and h) Tumor cells of ALK-negative anaplastic large cell lymphoma are negative for the respective markers. (i) Hodgkin and Reed-Sternberg cells are negative for CAPN2, whereas a subset of lymphocytes is positive. Inset: classical Hodgkin lymphoma case with CAPN2-positive Hodgkin and Reed-Sternberg cells. (j) Tumor cells of ALK− anaplastic large cell lymphoma show expression of CAPN2.

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