Figure 3
From: Familial colorectal cancer type X: genetic profiles and phenotypic features
Model illustrating identified genetic alterations that may promote tumorigenesis in FCCTX tumors. FCCTX are chromosomally instable with gains in chromosomal region 20q and complete loss of chromosome 18. These alterations may result in deregulation of genes involved in chromosomal segregation and genomic instability (AURKA), apoptosis (BCL2 and SERPINB5), proliferation (GNAS), growth inhibition, angiogenesis (PTGER1), and migration (SRC).
