Figure 1 | Modern Pathology

Figure 1

From: In vivo intratumoral Epstein–Barr virus replication is associated with XBP1 activation and early-onset post-transplant lymphoproliferative disorders with prognostic implications

Figure 1

Left panel displays a diffuse large B-cell lymphoma with latency III Epstein–Barr virus (EBV) infection pattern. (a) Tumor is composed of large atypical cells with immunoblastic features and admixed plasma cells H&E ( × 20). The atypical cells express intense (b) CD20 ( × 20), and are infected by EBV (c) EBER ( × 10), with expression of (d) LMP-1 ( × 20) and (e) EBNA-2 ( × 20). Right panel shows a polymorphic post-transplant lymphoma with (f) prominent plasmacytic differentiation H&E ( × 20) with low (g) CD20 expression and a latency II EBV infection pattern with expression of (h) EBER ( × 40), (i) LMP-1 ( × 40) but (j) negativity for EBNA-2 ( × 20).

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