Figure 2 | Modern Pathology

Figure 2

From: In vivo intratumoral Epstein–Barr virus replication is associated with XBP1 activation and early-onset post-transplant lymphoproliferative disorders with prognostic implications

Figure 2

(a) Intratumoral Epstein–Barr virus (EBV) replication and XBP1 expression. Left panel shows a case of diffuse large B-cell lymphoma without EBV replication, negative for BZLF1 ( × 20) and BMRF1 ( × 20) and negativity for XBP1 ( × 40) and without light chain expression. Right panel, depicts a polymorphic post-transplant lymphoma with high EBV replication, positive for BZLF1 ( × 20) and BMRF1 ( × 20) with high nuclear XBP1 expression ( × 40) and strong cytoplasmic light chain expression. (b) Western Blot for BZLF1. Cases 1, 3, and 4 correspond to highly replicative tumors; cases 2 and 5 correspond to low replication samples. (c) EBV replication is significantly higher in XBP1-positive cases (P=0.004).

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