Figure 3

Schematic representation of the FISH findings in six cases with at least two tissue spots affected by PTEN rearrangements. Black dots correspond to the centromere 10 probe, yellow and green dots represent the corresponding PTEN break-apart FISH signals. All six cases showed translocations of all present alleles, subsequent loss of the break-apart signals mostly starting at the green 3′ sequence, followed by the orange 5′ sequence and finally loss of all FISH signals. For reference, the spot pattern of a normal case (no deletion, no rearrangement) is indicated in the bottom left corner.