Table 1 Examples of lncRNAs with various modes of action in human cancers
From: Long non-coding RNAs in cancer invasion and metastasis
lncRNA | Size | Mode of action | Reference(s) |
|---|---|---|---|
HOTAIR | 2.2 kb | Chromatin remodeling | |
MALAT1 | ∼7 kb | Protein activity modulation; sensor; scaffold | |
LET | ∼2.2 kb | Protein activity modulation | |
H19 | ∼2.3 kb | Control of imprinting | |
ANRIL | ∼3.9 kb | Chromatin remodeling | |
lincRNA-p21 | ∼3.1 kb | Transcriptional co-repressor | |
RN7SK | 322 bp | Transcriptional regulation | |
GAS5 | 0.6–1.8 kb | Transcriptional repressor | |
TERRA | ∼2.0 kb | Enzyme inhibitor | |
aHIF | ∼1.6 kb | RNA decay | |
ncR-uPAR | 486 bp | Regulation of gene expression | |
PCGEM1 | ∼1.6 kb | Regulation of gene expression | |
CUDR | ∼2.2 kb | Regulation of gene expression |
