Table 2 Examples of potential lncRNAs associated with cancer invasion and/or metastasis
From: Long non-coding RNAs in cancer invasion and metastasis
Type | lncRNA | Genomic location | Cancer types | Function in cancer invasion and/or metastasis | References |
|---|---|---|---|---|---|
PRC pathway-related lncRNAs | HOTAIR | Intergenic, Hox C locus, 12q13.13 | Breast, liver, colon, stomach, nasopharynx, esophagus, skin | Gene silencing via interaction with PRC2 | |
PCAT-1 | Intergenic, 8q24 locus, 725 kb upstream of c-MYC | Prostate, colon | Gene silencing via interaction with PRC2 | ||
MALAT1 | Intergenic, Chr11q13 | Breast, lung, uterus, pancreas, colon, prostate, liver, osteosarcoma | Interaction with PRC1 leading to relocalization of metastasis-associated proteins | ||
Signaling transduction pathway-related lncRNAs | MALAT1 | Intergenic, Chr11q13 | Bladder | Promotion of EMT by activating the Wnt/β-catenin pathway | |
H19 | Imprinted at the Igf2 locus in Chr11, 11p15.5 | Bladder, liver | Promotion of EMT by activating the Wnt/β-catenin pathway | ||
CCAT2 | Unknown, 8q24 | Colon | Activation of the Wnt signaling pathway | ||
LET (NPTN intronic transcript 1) | Intronic, 15q24.1 | Liver, colon, lung | A tumor suppressor in the HIF-1α pathway | ||
Intronic lncRNAs (PPP3CB, MAP3K14 and DAPK1 loci) | Intronic, PPP3CB, MAP3K14 and DAPK1 loci: 10q22.2, 17q21 and 9q21.33 | Pancreas | Associated with the MAPK pathway |
